SARS-CoV-2 infection may increase risk of preeclampsia – Consumer Health News
In a cohort of patients with risk factors comparable to those in the study population, the prior risk of preeclampsia was approximately 1%. The researchers found that after excluding cases diagnosed before SARS-CoV-2 infection, the observed rate of preeclampsia was higher than expected: 1.9, 2.2, 5.7 and 11.1 % in asymptomatic patients and those with mild, moderate and severe disease. respectively; this monotonic relationship between the severity of COVID-19 and the risk of preeclampsia was statistically significant. By comparing the risk of preeclampsia between asymptomatic patients and patients with symptoms of COVID-19, the risk of preeclampsia was increased in association with severe COVID-19 (adjusted risk ratio, 4.9). Additionally, compared to people with asymptomatic or mild illness, the risk was increased for people with moderate or severe COVID-19 (adjusted risk ratio, 3.3). “We present evidence that the more severe the infection with SARS-CoV-2, the greater the risk of preeclampsia and preterm delivery,” write the authors. “Infection with SARS-CoV-2 can lead to endothelial dysfunction, intravascular inflammation, proteinuria, activation of thrombin and hypertension, all of which are hallmarks of preeclampsia. Therefore, a causal relationship must be considered.
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